Things have changed so much in the region since the attempted coup in Turkey that the regional alliances might be unrecognisable by November at this rate.
The latest flashpoint is in Hasakah.

First of all, consider that the U.S. is now throwing around threats.

Just when you thought US foreign policy could not get more absurd. Lt. Gen. Stephen Townsend, who is listed as “commander of US forces in Iraq and Syria,” has issued a warning to the Syrian military that if its counter-insurgency operations on Syrian soil leave US troops on Syrian soil “feeling threatened,” the US military would “defend itself.”

That needs to be broken down to even be believed.

The Syrian military is fighting an armed uprising on its own soil. The US government is training and equipping several factions of that armed insurgency, in this case the Kurdish YPG militia. The US military is also operating on Syrian soil alongside and in support of the YPG militia. Members of the YPG militia have, over the past several days, been firing on Syrian government forces. The Syrian air force returns fire on its own soil and the US military that is illegally operating on Syrian soil issues a warning to the Syrian government to stop firing on insurgents on Syrian soil!

This is a good moment to remind you that Obama promised "no boots on the ground" in Syria 16 times, and there is no AUMF for our forces to even be there.
This would be considered a disaster, unless you consider it an opportunity.

Lt. Gen. Townsend pointedly threatened both Russia and Syria over recent flights and airstrikes around the northeastern city of Hasakeh.
Townsend said he’d “informed” the Russians that US warplanes are prepared to defend US troops on the ground if they feel threatened in future strikes in and around Hasakeh....
US officials, on the other hand, seem to see this as a great opportunity to transition from the war against ISIS, which despite all their rhetoric isn’t accomplishing much, and into a war against Syria’s government, which they see as a more straightforward, and potentially more winnable, battle.
US intelligence officials have been arguing that point since last year, and State Department officials have also been pushing the idea of shifting the war to one of regime change, on the idea that the pro-US rebels are never going to get anywhere unless the US props them up as a government first.
That said, attacking Syrian warplanes over Syria is almost certain to quickly bring the Russians into the war as well, which is why it has in practice been unthinkable to do so. Despite that obvious problem looming just over the horizon, however, US officials are still eagerly rushing forward on a confrontation.

Yeh, nothing like taking on both Damascus and Moscow after 15 years of failing to defeat al-Qaeda and the Taliban.
Has anyone considered that maybe this is a fight we shouldn't be involved in? A fight that the American people don't want? A fight that easily lead to a bloody quagmire?

Meanwhile, Turkey has promised to "be playing a more active role" in Syria. To demonstrate this new policy, they are preparing to invade Syria with their own rebel army.

The rebels, Turkish-backed groups fighting under the banner of the Free Syrian Army (FSA), are expected to assault Jarablus from inside Turkey in the next few days, said the rebel official, who is familiar with the plans but declined to be identified.
"The factions are gathering in an area near the border (inside Turkey)," the rebel said.
Another rebel source said they were gathering at a Turkish military camp near the town of Qarqamish just opposite Jarablus.

The rebel forces are mostly being drawn from non-ISIS jihadists.
Consider that just the other day, Turkey and Iran agreed on a Syrian peace plan. Since they back opposite sides in this war, that seems bizarre. But they have something in common.

However, Turkey and Iran have large Kurdish communities and both appear to be concerned about Syria's Kurds gaining more areas under their control on the border with Turkey. Ankara also considers the YPG a terrorist organization because of its links to Turkey's outlawed Kurdistan Workers' Party, or PKK.

In fact, this Turkey-Iran alliance is exactly what the Syrian Kurds are blaming for this new conflict.
Turkey is quickly building alliances with Russia since the coup.

Lastly, has everyone already forgotten that our allies in Iraq are fighting on the side of the Assad government, and might not be happy about this new war?

Since fighting broke out in Syria on March 18, 2011, young Iraqi Shiite fighters of several other militias, including the Brigade of Abu al Fadl al Abbas, the Zulfikar brigade and the Iraq Hezbollah brigades, have been flocking to Syria to fight alongside the Syrian army and its ally, Lebanon's Shiite Hezbollah, against the mostly Sunni Syrian opposition factions...
This Shiite need to widen the conflict to places with Shiite holy sites led some to accuse Shiites of fighting a proxy war for Iran in Syria.

After 15 years of failing to defeat sheep herders with AK-47s, lets start a war against Damascus, Tehran, Baghdad, Moscow, and maybe Ankara just for kicks! Why not!