COVID-19 update: the eyes may have it but the nose knows. A hot topic: fever
Time for serious contemplation once again about the flourishing pandemic. A recent essay entitled the nose knows has been submitted for your erudition. Loss of the sense of smell, which sensation is called olfaction, is called anosmia. Hyposmia is a milder form of diminished olfaction. In the above cited essay, the loss of olfaction has lately been realized to be of possible diagnostic significance. The MedCram video is referred to below, from which also are taken several illustrations, also included here.
Loss of olfaction, anosmia, has been the only symptom reported in otherwise asymptomatic individuals who test positive for the virus. So, if anyone in your family or social/work environment has suddenly decreased or absent olfaction, advise that person he/she may be infected. Then self-quarantine because...tag, you're it.
Hat tip to Raggedy Ann for bringing up fever and fever treatment. Previously, I wrote that one should avoid fever treatment. Dr Sejheult's MedCram video clarifies exceptions to that rule as well as explaining how fever combats infections, not just viral ones.
Briefly, fever enhances certain cytokines, intracellular and circulating chemical messengers, to help destroy invaders (although not cancer, as I understand it). This effect is mediated by A20, another in the enormous list of cytokines.
Acetaminophen (Tylenol, paracetamol), aspirin, and all other NSAIDS, suppress metabolic reactions enabling the body to fight off infections. Please watch the video.
Diagrams are often helpful illustrating ideas, processes, etc. Here are a few:
Graphic depiction of effect of good and not good immunity in COVID-19
General effect of NSAIDS on infection:
Specific action of NSAIDs in COVID-19 infection:
The spike protein (S-protein) mediates receptor binding and membrane fusion. Spike protein contains two subunits, S1 and S2. S1 contains a receptor binding domain (RBD), which is responsible for recognizing and binding with the cell surface receptor. S2 subunit is the "stem" of the structure, which contains other basic elements needed for the membrane fusion. The spike protein is the common target for neutralizing antibodies and vaccines. It's been reported that SARS-CoV-2 (2019-nCoV) (ref.) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. Indeed, the recombinant Spike protein can bind with recombinant ACE2 protein.
The Nucleocapsid Protein (N-protein) is the most abundant protein in coronavirus. The N-protein is a highly immunogenic phosphoprotein, and it is normally very conserved. The N protein of coronavirus is often used as a marker in diagnostic assays.
To aid the efforts of developing vaccines and neutralizing antibodies against this virus, Sino Biological Inc. has developed a panel of research reagents for SARS-CoV-2, including recombinant antigens (the N protein, S protein, the S1 and S2 subunits of the S protein, and the RBD domain of the S proteins), antibodies, antigen detection kits and genes.
Tests performed on nucleic acid residues, PCR, are slower to perform and according to the linked article less sensitive than tests to detect immunogenic protein caused by viral infection; in other words, DNA unneeded for the faster protein-based testing.
The eyes have it
Conjunctivitis, inflammation of the whites of the eyes, is a sign of infection with COVID-19. Dr. Wen Liang, martyred by the CCP, was the first to publicly state there was a "new kind of pneumonia. Dr Wen was an ophthalmologist. And thus this pink eye sign connotes likely COVID-19 infection during this pandemic. If one has no pink eye, wear contact lenses but clean them carefully in bactericidal solution as suggested by the lens manufacturer.