Susan Grigsby at TOP wrote an excellent review of a study by Case and Denton which showed a large disparity especially in non-college educated (I would probably suggest "blue collar") white men, suicide, opiate overdose, and death from other groups.

Their report, titled "Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century,” was published in PNAS (Proceedings of the National Academy of Sciences)