Would you accept to participate in a vaccine clinical trial against Covid-19 before animal tests were complete? ?
@JtC (are their ways to embed a yes/no counter in an essay page?)
This is an automated translation of the German article of "Der Spiegel - Science"
here. (I did not edit it)
The risky race of the pharmaceutical companies
Research into a new vaccine against Covid-19 is under high pressure. Common rules are now being softened in drug development. That poses dangers.
Martin Schlak reports from Boston
14.03.2020, 2:08 p.m.Up to half a milligram should be injected into the test subjects, divided into two doses. There is $ 1100 compensation for participation. It is in the guidelines for the world's first study in which people are given a possible vaccine against Covid-19. A research institute in Seattle, USA has recently started looking for 45 volunteers. The US vaccine manufacturer Moderna announced that the first doses could be injected later this month.
Vaccines have never been developed as quickly as in the case of Covid-19. In addition to Moderna, other pharmaceutical companies say they are about to carry out human tests. In the race against the deadly pathogen, experimental substances should now be administered to people before their efficacy has been extensively researched on experimental animals - a break with a noble principle of pharmaceutical research. While some scientists find this haste appropriate, others warn of incalculable risks.
Testing a new vaccine is a highly complex, multi-stage process. As a rule, national regulatory authorities only give the green light for clinical studies, i.e. tests on humans, if both the safety and the effectiveness of a substance has been demonstrated on laboratory animals. This applies, for example, to the powerful American Food and Drug Administration (FDA). The WHO is said to have given the green light for accelerated procedures
The authorities often want to see not only the results of experiments on mice, but also on more highly developed animals, guinea pigs, rabbits or primates. Such studies can take months, sometimes years. Time that is not available in the event of a pandemic.
At a meeting of the World Health Organization (WHO) in mid-February, representatives of public research institutions and pharmaceutical companies discussed how the process could be accelerated. According to media reports, they agreed that because of the acute threat from the virus, vaccine developers should begin testing on humans before all animal studies are complete.

Comments
I would not volunteer to test the vaccine ... I am a coward.
How much would you ask to be compensated for taking the risk and volunteer as a human guinea pig, before the real guinea pigs had been tested successfully?
If you get paid for it, were you bribed? At what price do you break and offer yourself? What is the ethical dilemma here. I can't think clearly now.
https://www.euronews.com/live
No there's not...
But folks can weigh in yes or no in their comments.
thx. ... Way in folks ... :-)
https://www.euronews.com/live
No. I’m old. I’m in an at-risk group.
"The object of persecution is persecution. The object of torture is torture. The object of power is power. Now do you begin to understand me?" ~Orwell, "1984"
No, same reasons.
Ditto for me due to high risk. My adult kids?
I don't know what they would say. I will ask them. Have a feeling my son would decline and my daughter would say, "absolutely".
I believe my brother committed covid19 suicide, or at least attempted to; we shall see.
He abhorrently despises pretty much any large social gathering (people in grocery stores seriously piss him off, though I can relate), but went to the Houston Livestock Show and Rodeo on Sunday. He also planted flowers instead of food, this year.
His financial situation is grim, and has declined in the last year, substantially.
He had an organic urban garden, in what used to be called, "The Montrose" . I've eaten the most glorious (and persistent) collard greens I've ever had from it for years, as well as herbs and other veggies.
Time for a text, and maybe a call if he's up. I just realized what he did. I will not rag on him and will try not to cry.
Not too likely there’d be much time
for a vaccine to stimulate antibody production before I am likely to be exposed. In the much less likely event that I avoid becoming infected, there’s a very real possibility that the vaccine might result in an active infection or even kill me oughtright.
No speedy vaccine for me. I’m content to roll the dice and wait like everyone else for a properly vetted vaccine a year or two down the road.
“The story around the world gives a silent testimony:
— The Beresovka mammoth, frozen in mud, with buttercups in his mouth…..”
The Adam and Eve Story, Chan Thomas 1963
I also find myself resistant to lining drug profiteers pockets.
Now if the vaccine were to be made available at cost or at no cost and without patent protection, then I might reconsider my position.
“The story around the world gives a silent testimony:
— The Beresovka mammoth, frozen in mud, with buttercups in his mouth…..”
The Adam and Eve Story, Chan Thomas 1963
No
I am something of an anti vaxxer for myself. I rarely get sick and when I do it is a mild version of whatever it is that is going around. I have worked in public or the equivalent of a giant airplane with recycled air for 35 years. I believe I have been exposed to just about everything out there plus I seem to have great genetics. My mother went 96 years without taking an antibiotic. When asked if she was allergic to penicillin she didn't know. The doctor glared at her with a raised eyebrow like she was an alien life form. At 58 I have never needed an antibiotic either. I think I will continue to trust that, it got me this far.
Fucking propagandists at Heritage Foundation
EDIT: Maybe I shouldn't have posted this in this diary. Should I delete it?
EDIT 2: I published a diary with this info.
National Security Adviser Robert O'Brien spouts lies and misconceptions about how China has handled the COVID-19 outbreak.
I'm so pissed at this asshole I'd like to give him a hard kick in the ass to dislodge his head.
[video:https://www.youtube.com/watch?v=ENxG80iLdpE&t=19m30s]
Read the following timeline on Wiki. All the events occurring in China were publicly available. The WHO was involved almost from the very beginning.
If you watch O'Brien's talk from the beginning of that video, he speaks about the necessity of expanding and increasing the Defense Budget to counter new threats to American hegemonic world power. The US is the greatest threat to human health and existence on the face of the earth.
The following is the gist of O'Brien's talk. But you should really watch the video because he praises Trump, Pence and Pompeo for getting a firm handle on the problem.
I'm looking forward to the US version of China's response to COVID-19
Maybe hope is on the horizon
The massive war games in Europe on still on
20,000 US troops will play with their guns along with 10,000 defenders from other countries. One article I read on this said that no one had been given masks.
But then the military has already failed big time for when they took the quarantined folks off the cruise ship after they had been separated in their rooms there they loaded them all on buses and then they sat on them for hours. And people took off their masks to eat and drink. Well done.
To learn who rules over you, simply find out who you are not allowed to criticize.
- Kevin Alfred Strom
I will need more time tomorrow or later
to exactly understand the clinical trial procedures.... and other things, I don't understand fully. Thank You upfront for your comment.
PS. In Berlin, Germany all gatherings with more than 50 people are not 'verboten', starting tonight.
My brother in a small town near the lake Lago Maggiore in Switzerland, is not allowed to leave the town's geographical borders anymore. Too close to the Italians ...
One good idea in Switzerland is a new service for anyone, who is too old or weak to do their food supply shopping. You can call them (on land lines too), order items you need, they get out and buy them for you and deliver them to your home, which includes bringing the boxes to your kitchen. I am not sure if it costs extra for delivery. It's a group community effort. (With the mountains and the houses often on steep hills, that is a good idea)
Meanwhile the virus infection hit some media folks and TV talk shows with political talking heads on their round table. They have no studio audience anymore. Looks and sounds quite strange.
Ironically in areas where tourism is a main source of income, hotels themselves send the tourists home and arrange for them to do it ... asap. They don't want the customers anymore. Apparently they prefer an empty hotel It's weirdo, but somewhat thought provoking.
PS. Trump has been tested? You think the results will be published, if he tested positive? Well, in case he is postivie, he at least has the safest quarantine quarters in the world. /s And if he tested negative, who would believe those media who try to make us believe it's true" /s
https://www.euronews.com/live
@mimi reported to be negative
yeah I read it ... sigh ... thanks /nt
https://www.euronews.com/live
So, let me see
if I understand this right.
I'm to take the vaccine and then expose myself to the virus to see if it works?
Hmmm.
Uh, no.
Neither Russia nor China is our enemy.
Neither Iran nor Venezuela are threatening America.
Cuba is a dead horse, stop beating it.
As I understand it from my readings
@earthling1 They would test to see
I probably would
I would have to have a good look at the nature of the vaccine (attenuated virus, dead virus, viral proteins) and ascertain the risk. The best we can do now is to try to minimize infections until a vaccine is ready and do the best we can under what is laughably called the US health care system to deliver the best supportive care for people that are seriously ill from COVID-19. We don't have enough hospital beds or respirators. People will die because we have a breathtakingly stupid health care system. Looking at you Barak Obama, Joe Biden, and all the arrogant neoliberal assheads in both parties. If you had consciences and enough intelligence to realize how pitifully stupid you are, you would apologize to the people of the US and world for the harm you have done and STFU for the rest of your lives.
The ICU hospital bed situation is the same here in Germany
if that makes you feel better. It's the virologists who have some influence on the politicians. That is new.
https://www.euronews.com/live
I would volunteer in a heartbeat
Moderna's vaccine is an mRNA based vaccine that, when injected, will make a small fragment of coronavirus protein that hopefully will be recognized by the immune system and start the production of antibodies to prevent an infection. There would be no chance to get the COVID-19 disease from the vaccination as it wouldn't contain all of the components necessary to generate an live virus. I think that historically, vaccine making has been one of the most safe and effective methods of combating infectious diseases. We are now living through a time with this pandemic that used to be much more common in human history. Vaccines have made it so we don't often think about polio, measles, whooping cough and many other common illnesses that used to worry all parents raising young kids. Vaccines have even eliminated smallpox, the most deadly viral pathogen known to mankind. Relative to any other medical intervention, vaccine development has been incredibly safe, even in the early days when live virus was commonly used. This coronavirus is going to stick around until a good vaccine is developed and I would be happy to be a guinea pig since this testing will save lives in the very near future
Now this is a good answer! Thanks.
So that's pretty cool that their approach could work.
I wonder as well though what the failure/success rate is on their vaccine trials. I would imagine that any vaccine candidate would have already gone through a lot of testing, along with hundreds of others, to make sure that cells in tissue culture exposed to the "mRNA" take up and express the protein fragment they are meant to at high levels, that the bit of viral protein they "express" is found in an exposed part of the virus and that antibodies targeted to that region of a protein will result in virus infected cells being dutifully killed.
But, trust me, there is a bit of an art to protein sequence "gazing" such that regions of a protein are chosen that work well for a vaccine. There are no algorithms that work well to find regions that are both highly expressed in the cell *and* make a protein that will prove to be antigenic *and* protective. It is, in my experience, a best guess scenario and some folks seem to have a serendipitous knack and others don't.
Either way, yeah I'd probably be OK with testing the vaccine. I would like to know what else is in the sample being injected (adjuvant etc?). But, I think bad outcomes from this type of test would be really rare.
As an aside, a few folks near the top commented that they would not risk the injection because they are in a "high risk" group. I think the assumption is that there is the possibility they might get the disease itself from the vaccine. This is not the case. We are talking about injecting a tiny part of the virus. We are past the days that attenuated (e.g. heat "killed") or any other such formulation that might contain some "live" virus would be a formulation that would be used for vaccines.
Edit: deleted a "not" that changed the meaning of a sentence...
link to updated info about virus in Europe and some drumpcrap
I read this one regularly. It's updated all the time. I then put each new update in something like the google translate page to get and English version. May be you want to do that too?
Corona Virus News
This bit of information I found 'telling':
In German:
English translation via google translation:
Me sez: Under 'Virus Law' you are all equal, according to the Viral Law Supreme Court. Get that, Mr. Crap.
https://www.euronews.com/live