I didn't dare to hope, but it seems it has actually happened: CETA is dead. The 'Trade' agreement between Canada and the EU has foundered on resistance by s single group within a single EU nation, the Belgian region of Wallonia blocked the country's acquiescence to the Comprehensive Economic and Trade Agreement, a pact between Canada and the EU which would subject EU countries and Canada to devastating financial penalties meted out by an unaccountable panel of corporate cronies using the dreaded ISDS.
The main Canadian negotiator, International Trade Minister Chrystia Freeland, stormed out in frustration, giving up on sneaking the destruction of democratic self-determination through in time for the upcoming EU-Canada summit:

"It's become evident for me, for Canada, that the European Union isn't capable now to have an international treaty even with a country that has very European values like Canada. And even with a country so nice, with a lot of patience like Canada."
"I've worked very, very hard, but I think it's impossible," the minister said, reflecting on the months of travel and lobbying across Europe she's invested personally in trying to garner enough support, working in tandem with her EU trade counterpart, Cecilia Malmstrom.

"We have decided to return home. I am very sad. It is emotional for me," she told reporters. "The only good thing I can say is that tomorrow morning I will be at home with my three kids."

While it is unclear whether she is ignorant, or evil, or both, I am concerned for the well-being of children in the care of a rapacious tool of corporate lobbyists.

The failure of the negotiation hinged on the infamous Investor State Dispute Settlement (ISDS) system which allows Canadian or European companies, or hedge funds that buy them, to extort large sums from governments if they can convince a group of private arbitrators in secret proceedings that some act or lack of action by the government has impinged on their imagined future profits.

CETA could be blocked due to an earlier ruling that required unanimous consent from all EU countries for the 'trade' deal, as well as accords between regional factions in Belgium that gave more autonomy to the regions. Ironically this was mostly accomplished by the Flemish Nationalists, who strongly supported CETA and now regret Wallonia's autonomy:

For decades, Flemish nationalists have torn Belgium apart, shifting increasing powers to the country’s regions. Now, they are stuck in a federal government immobilized and embarrassed by those very regional powers they fought so hard to win.

“It’s pretty embarrassing,” said Carl Devos, politics professor at Ghent University. “If you advocate rights for regions … you can’t just say those rights then need to be violated.”

The New Flemish Alliance (N-VA), Belgium’s largest party and Flemish-nationalist powerhouse, is particularly haunted by Wallonia’s obstruction over the Comprehensive Economic and Trade Agreement with Canada. The party wields the power at the federal level but can’t force the southern region to abide by its wishes.

So at this point, it is clear that the rhetoric of regional autonomy and national self-determination has come back to haunt those who employed it cynically while attempting to subjugate it to corporate control.

“Their resistance is putting the [French-speaking] Socialist Party on the map internationally — but above all, they need to get back on the map in Wallonia,” said Sinardet.

Rallying against multinationals will not hurt their prospects. Wallonia has clashed with multinationals, as their industry declined over the decades and corporate cut-backs sparked job losses.

Wallonia’s rebellion is welcomed by a political minority in Flanders too.

“If the N-VA has to choose the side of the multinationals’ lobby and other interests, they take the multinationals’ side,” the opposition’s Flemish Socialists’ president John Crombez said, raging against the CETA deal.
“People pleading for the importance of trade could be right, but that’s really not the point. It’s the clauses,” Crombez said about CETA’s mechanisms for companies to sue governments. “Get those clauses out if you’re really serious about trade.”