A recent Gallup poll shows that 72% of Pakistanis view the U.S. as an enemy, rather than an ally. This past year has proven their mistrust of America to be sound and logical.

It started last February, when then Pakistani Prime Minister Imran Khan signed a huge trade deal with Russia.

“It is very clear that this visit is at a critical juncture as the Ukraine crisis is sweeping the entire world. So it becomes even more important because it could be seen as taking sides with Russia. The fallout could be serious,” Imtiaz Gul, executive director for the Center for Research and Security Studies, told VICE World News.

PM Kham stressed in a televised address to the nation that he wanted a ‘free and independent’ foreign policy. Within just two weeks, Khan claimed there was a coup plot afoot that had foreign backing.

“We received a threat in writing and I have the evidence,” Khan said during a speech for party supporters at a rally in the capital.

Just days later Pakistan's parliament moved to have a no-confidence vote for Khan. The United States moved to pick sides.

Khan claimed that Lu warned the Pakistani envoy to the US, Asad Majeed, that there would be "implications" if the Pakistan prime minister survived the no-trust vote in the National Assembly.

Not surpisingly, Khan was ousted. The Prime Minister chosen to replace him was Shehbaz Sharif, younger brother of the former Prime Minister Nawaz Sharif, who was named repeatedly in the 2016 Panama Paper leak.
In 2020, the Pakistani government filed a huge money laundering indictment against Shehbaz Sharif and his family.

He said the case comprised 55 volumes and 25,000 pages of documentary evidence against the Sharifs, including company records, bank statements and foreign remittances. The record was compiled after detailed investigation by NAB teams which nominated 16 accused in the case six family members and their 10 accomplices, Akbar said, adding that four of the accused had turned approvers and disclosed their role in money laundering carried out by the Sharif family.

He said billions of rupees were laundered through employees of the companies owned by Shahbaz and his children. Akbar accused Shahbaz and Hamza of taking kickbacks and commissions in return for party tickets and projects to favourites.

Shehbaz Sharif was held in prison for 20 months and was only released on bail in April of 2021. At which point he was incredibly immediately elected the new Prime Minister of Pakistan.

"A man who has one corruption case of 16 billion rupees and another corruption case of 8 billion rupees against him...for that person to be selected and elected as the Prime Minister, there cannot be a bigger insult to the country. We are resigning from the National Assembly," Imran Khan was quoted as saying by PTI's official Twitter account.

It's absolutely bonkers that a guy who spent nearly 2 years in prison for a slam-dunk case of money-laundering, would get released on bail and then elected by parliament (note, not by the people of Pakistan) to be the leader of the country practically the same day.
Yet that is essentially what happened. So guess what was the new Prime Minster's very first priority? Taking care of America's financial interests.

To ousted leader Imran Khan, Pakistan’s new prime minister is simply a “slave of America” who conspired with the U.S. to remove his government and reorient the nation’s foreign policy...
Khan rallied supporters across Pakistan Sunday night to protest what he called “U.S.-backed regime change,” and dozens of lawmakers in his party resigned Monday to pressure Sharif.
The discord threatens to complicate Sharif’s talks with the International Monetary Fund to secure $3 billion remaining from a loan program to shore up the nation’s finances. Pakistan’s stocks and rupee soared on Monday on optimism at obtaining the funds, which were held up after Khan cut fuel and electricity prices to help the country’s 230 million people cope with Asia’s second-fastest inflation.
...In his first remarks after taking power on Monday, Shehbaz Sharif said he would hold a public hearing on Khan’s claims that the U.S. sent his government a threatening letter and vowed to resign “if there is any iota of conspiracy.” Shehbaz Sharif pledged good ties with “all-weather friend” China while also seeking better ties with the U.S. and Europe. He made no mention of the IMF as he vowed to turn Pakistan into “a paradise for investment through wonderful policies.”

Some months later former-PM Khan was shot and nearly killed while leading a protest march, while Sharif continues to refuse to hold new elections.
Meanwhile, in order to get some of that sweet IMF loans, Shehbaz Sharif cut gas and electricity subsidies for the working class of Pakistan, while dramatically raising regressive taxes that target the poorest in Pakistan.